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Tests verifying that adequate perfusion exists are a part of a patient’s assessment process that are performed by medical or emergency personnel. During major surgery, especially cardiothoracic surgery, perfusion must be maintained and managed by the health professionals involved, rather than left to the body’s homeostasis alone. In 1920, August Krogh was awarded the Nobel Prize in Physiology or Medicine for his discovering the mechanism of regulation of capillaries in skeletal muscle. Malperfusion can refer to any type of incorrect perfusion though it usually refers to hypoperfusion. The meaning of the terms “overperfusion” and “underperfusion” is relative to the average level of perfusion that exists across all the tissues in an individual body. In the case of skin cells, extra blood flow in them is used for thermoregulation of a body. Many types of tumors, and especially certain types, have been described as “hot and bloody” because of their overperfusion relative to the body overall. Overperfuson and underperfusion should not be confused with hypoperfusion and hyperperfusion, which relate to the perfusion level relative to a tissue’s current need to meet its metabolic needs.
In equations, the symbol Q is sometimes used to represent perfusion when referring to cardiac output. Microspheres that are labeled with radioactive isotopes have been widely used since the 1960s. Radioactively labeled particles are injected into the test subject and a radiation detector measures radioactivity in tissues of interest. In the 1990s, methods for using fluorescent microspheres became a common substitute for radioactive particles. The first is based on the use of an injected contrast agent that changes the magnetic susceptibility of blood and thereby the MR signal which is repeatedly measured during bolus passage.
Perfusion can be determined by measuring the total thermal diffusion and then separating it into thermal conductivity and perfusion components. CBF is usually measured continuously in time. Retrieved March 20, 2008, from Dictionary. The measurement of diffusion and perfusion in biological systems using magnetic resonance imaging”. Fully quantitative cardiovascular magnetic resonance myocardial perfusion ready for clinical use: a comparison between cardiovascular magnetic resonance imaging and positron emission tomography”.
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Nobel prize for August Krogh in 1920 for his discovery of regulative mechanism in the capillaries”. Studies of the Circulation with Radioactive Microspheres. Applications of arterial spin labeled MRI in the brain”. Journal of magnetic resonance imaging: JMRI.
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